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The CCR5–02 mAb does not interfere with JRFL gp120 binding to the CCR5 receptor. Iodinated 125I-labeled JRFL gp120, produced from recombinant vaccinia virus, was bound to HEK-293 cells transfected with plasmids expressing the indicated receptors. Shown are representative raw values of binding in the presence or absence of the indicated antibodies. Background binding to pcDNA3-transfected cells has been subtracted.
