FIGURE 1.

Primary and secondary structures for REF2-I and alignment with ALY. The secondary structural elements for murine REF2-I determined using NMR are shown above the sequence. The regions of each protein analyzed using NMR techniques are shown in bold. A schematic of the principal regions of REF2-I referred to in the text is shown below the sequence alignment. Flexible hinge regions are shown as blue loops above the sequence alignment on the basis of ¹⁵N[¹H] NOEs (Fig. 6B).