Table 1.
Frequency of spontaneous EAE in PLP TCR-transgenic mice
| Generation | 4E3
|
5B6
|
|||||||
|---|---|---|---|---|---|---|---|---|---|
| 1736
|
1740
|
1858
|
|||||||
| Incidence | Severity | Gender | Incidence | Severity | Gender | Incidence | Severity | Gender | |
| F1 | 1/13 (8%) | 2.5 | 1F | 0/7 (0%) | N/A | N/A | 0/4 (0%) | N/A | N/A |
| N2 | 1/6 (16%) | 2.0 | 1F | 3/11 (27%) | 1.7 | 3F | 3/12 (25%) | 1.5 | 1M, 2F |
| N3 | 5/6 (83%) | 2.0 | 5F | 1/7 (14%) | 3.0 | 1M | 2/5 (40%) | 2.8 | 2F |
| N4 | N/A | N/A | N/A | 1/8 (13%) | 3.0 | 1M | 6/9 (67%) | 2.4 | 2M, 4F |
| N5 | N/A | N/A | N/A | 9/15 (60%) | 2.2 | 7M, 2F | 8/28 (29%) | 2.2 | 4M, 4F |
| N6 | N/A | N/A | N/A | N/A | N/A | N/A | 9/20 (45%) | 1.9 | 4M, 5F |
4E3 (1736, 1740) and 5B6 (1858) TCR-transgenic mice on indicated SJL backcross generations were monitored regularly for signs of EAE for at least 6 months. Numbers of transgenic mice with spontaneous EAE per total number of transgenic mice in each generation are shown, and resulting frequencies of spontaneous EAE are given in percentages (%). Severity is shown as mean peak disease severity. M, male; F, female; N/A, not applicable.