Table 1.

Effect of dietary cholesterol on plasma cholesterol levels, bile flow, and biliary lipids output in WT and apoE knockout mice

Animal group (n)	Plasma cholesterol, mg/dl	Biliary cholesterol	Biliary phospholipids, μg/g body weight/h	Biliary bile acids	Bile flow*
E+/+ 0.02% (10)	66  ± 12	0.73  ± 0.14	15.6  ± 2.9	63.7  ± 18.4	3.01  ± 0.88
E+/+ 0.5% (10)	67  ± 12	3.30  ± 0.81‡	26.6  ± 5.5‡	107.3  ± 44.5§	5.09  ± 1.06†
E−/− 0.02% (14)	403  ± 178	0.82  ± 0.15	20.0  ± 8.3	66.8  ± 24.9	3.22  ± 0.96
E−/− 0.5% (14)	788  ± 256	1.70  ± 0.47†	22.6  ± 4.9	76.3  ± 25.9	4.68  ± 1.42§

^*μl bile/g body weight/h. 

^† P < 0.0003; ^‡P < 0.0001; ^§P < 0.02, compared to 0.02% group of the same genotype.