Figure 2.

Histological features of the K5 GLI-1 transgenic skin. (a) Nodular BCC from founder 2 with palisading basaloid cells forming tumor nests (T) and retraction space of stroma from tumor islands (R). (b) Human nodular BCC. (c) Superficial BCC from founder 2 with buds and irregular proliferations of tumor tissue attached to the undersurface of the epidermis (arrow). (d) Human superficial BCC. (e) Cylindroma from founder 2 with tumor islands forming a jigsaw puzzle. (f) The periodic acid/Schiff reagent-positive hyalin membrane surrounding the cylindroma tumor islands (arrow). (g) TE from founder 1 with keratinized centers (arrow) surrounded by basophilic tumor cells. (h) Trichoblastoma from founder 3 illustrating tumor islands consisting mostly of germinative cells (arrow). Bar = 135 μm (e), 54 μm (a–d and g, h), and 33 μm (f).