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Conservation of amino acids that are predicted by ClustalW [20] to change by three missense mutations identified in this study. a p.Arg14Gly of pt 23; b p.Tyr1482Cys of pt 15; c p.Asp1543Tyr of pt 46. The changed residues are conserved in man (GeneBank: Q92793), in mouse (GeneBank: P45481), in Drosophila melanogaster (DROM3A), in Caenorabditis elegans (CEL116) and in P300 protein.
