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Fate of the 125I-hCG internalized by 293T cells expressing the myc-hLHR-wt or mutants thereof
| 125I-hCG (% of initial cpm internalized) | |||||
|---|---|---|---|---|---|
| hLHR | Leupeptin | Intracellular | Recycled | Degraded | |
| Surface- bound | Released undegraded | ||||
| Wt | - | 25 ± 1 | 34 ± 1 | 21 ± 3 | 20 ± 3 |
| + | 30 ± 1 | 32 ± 2 | 30 ± 3 | 8 ± 2 | |
| t682 | - | 27 ± 1 | 14 ± 1 | 15 ± 1 | 44 ± 2 |
| + | 61 ± 1 | 14 ± 1 | 19 ± 1 | 6 ± 1 | |
| L457R | - | 50 ± 2 | 42 ± 4 | 5 ± 1 | 3 ± 1 |
| + | 46 ± 1 | 46 ± 1 | 6 ± 1 | 2 ± 1 | |
| L457R/t682 | - | 57 ± 3 | 9 ± 1 | 5 ± 1 | 29 ± 3 |
| + | 83 ± 1 | 13 ± 1 | 3 ± 1 | 1 ± 1 | |
