Figure 8. IKK2 depletion promotes muscle regeneration.

(A–F) Trichrome staining of injured TA muscle sections from Ikk2^f/f and Ikk2^mko mice. (A and B) Extensive necrosis in both genotypes 2 days after CTX injection. Areas with infiltrated cells are marked with white arrows. (C and D) Recovery of the injured muscles in regenerating myofibers containing centralized nuclei (arrowheads) 5 days after injury. (E and F) Improved Ikk2^mko fiber morphology after 10 days. Intercellular space is marked with asterisks. (G) Increased CSA in the Ikk2^mko regenerated fibers. (H) Regenerating myocytes containing centralized nuclei close to injured area in the Ikk2^mko injured muscles (n = 5).