Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Nov 7;171(3):559–568. doi: 10.1083/jcb.200504015

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 4. — Induction of fibroblast apoptosis by CCN1–integrin interaction. (A) Effects of integrin-binding defective CCN1 mutants in apoptosis in Rat1a fibroblasts. Cells adhered to 6-well tissue culture plates were either left untreated or treated with 10 μg/ml of soluble wild-type CCN1; 10 μg/ml of the mutants SM, DM, or TM; or 10 μg/ml D125A for 24 h, and apoptosis was assayed. (B) Integrin requirements of CCN1-induced apoptosis in HSF. Cells adhered to 6-well plates were either left untreated or pretreated with 50 μg/ml of antibodies against integrin α₆ (GoH3), β₁ (P5D2), α₅ (P1D6), α_vβ₃ (LM609), or control IgG for 1 h. 10 μg/ml of soluble CCN1 was added where indicated and apoptosis was assayed 24 h thereafter. Error bars represent ± SD from experiments done in triplicate.