Table 3.
Unadjusted, adjusted, and multivariate analyses of factors influencing the ability to obtain nipple aspirate fluid (NAF), Sartorius Nipple Aspirate Fluid Cohort, 1970–1990.
| No NAF Obtained | NAF Obtained | Chi-square | Age-adjusted Odds | Multivariate* adjusted Odds | |||||||
| VARIABLE | N (%) | N (%) | p-value | Ratio | 95% CI* | p-value | Ratio | 95% CI | p-value | ||
| Marital Status | |||||||||||
| No | 617 (60.8) | 398 (39.2) | |||||||||
| Yes | 988 (53.9) | 845 (46.1) | 0.0004 | 1.39 | 1.19 | 1.63 | <0.0001 | 1.30 | 1.06 | 1.59 | 0.01 |
| Age at Menarche | |||||||||||
| 13 and older | 981 (62.3) | 595 (37.8) | 0.004 | 1.19 | 1.01 | 1.41 | 0.04 | 1.18 | 0.98 | 1.43 | 0.08 |
| 12 or younger | 548 (56.5) | 422 (43.5) | |||||||||
| Pregnancy History | |||||||||||
| Never pregnant | 546 (61.6) | 341 (38.4) | |||||||||
| Ever pregnant | 1183 (54.9) | 972 (45.1) | 0.0007 | 1.66 | 1.40 | 1.97 | <0.0001 | 1.55 | 1.24 | 1.94 | 0.0001 |
| Breastfed Children | |||||||||||
| Never Breastfed | 483 (55.5) | 387 (44.5) | |||||||||
| Ever Breastfed | 663 (54.8) | 546 (45.2) | 0.76 | 0.96 | 0.80 | 1.15 | 0.65 | ||||
| Menopause | |||||||||||
| No | 845 (52.8) | 755 (47.2) | |||||||||
| Yes | 838 (63.1) | 490 (36.9) | <0.0001 | 1.04 | 0.84 | 1.29 | 0.73 | ||||
| Estrogen Use | |||||||||||
| No | 1116 (56.1) | 755 (47.2) | |||||||||
| Yes | 580 (63.2) | 489 (36.9) | 0.02 | 1.23 | 1.02 | 1.48 | 0.03 | ||||
| Menopausal status and Estrogen use | |||||||||||
| Premenopausal women | 822 (53.3) | 721 (46.7 | <0.0001 | referent | referent | ||||||
| Menopausal and NO estrogen | 293 (62.9) | 173 (37.1) | 1.00 | 0.77 | 1.29 | 0.99 | 0.76 | 0.55 | 1.04 | 0.09 | |
| Menopausal and estrogen | 538 (64.2) | 300 (35.8) | 1.01 | 0.79 | 1.28 | 0.94 | 0.71 | 0.52 | 0.95 | 0.02 | |
| Oral Contraceptive Pills | |||||||||||
| No | 715 (63.6) | 409 (36.4) | |||||||||
| Yes | 873 (55.3) | 707 (44.8) | <0.0001 | 0.98 | 0.82 | 1.17 | 0.82 | ||||
| Tranquilizer Use | |||||||||||
| No | 1501 (59.8) | 1009 (40.2) | |||||||||
| Yes | 145 (39.7) | 220 (60.3) | <0.0001 | 2.50 | 2.00 | 3.15 | <0.0001 | 2.20 | 1.63 | 2.98 | <0.0001 |
| Endocrine Problems | |||||||||||
| Never | 1401 (58.6) | 992 (41.5) | |||||||||
| Ever had | 273 (53.7) | 235 (46.3) | 0.05 | 1.47 | 1.21 | 1.80 | 0.0001 | 1.39 | 1.07 | 1.81 | 0.01 |
* Multivariate model is adjusted for age, marital status, age at menarche, any pregnancy history, the combination of menopausal status and estrogen use, tranquilizer use, and endocrine problems (in the multivariate model N = 2104)
** CI, Confidence interval
Total number of women for whom NAF fluid was not obtained = 1729 (56.8%)
Total number of women for whom NAF fluid was obtained = 1314 (43.2%)
Total number of women, N = 3043