Figure 4.

Changed gene expression pattern following immunotherapy. Panel A: Hierarchical clustering analysis includes genes that tend to normalize after immunotherapy with respect to their gene expression levels detected in the normal control pools. In the SAA patient pool of bone-marrow derived T-cells 60 of 583 regulated genes turned to nearly normal gene expression levels after successful immunosuppression. Panel B: The comparison of the gene expression profiles from bone marrow-derived T-cells of the SAA pool before and after immunotherapy revealed several genes exhibiting a very high difference (> 4-fold) in their expression level.