Table 1.
patient | age/sex | diagnosis | PNH-clone | source of sample | pre-therapy sample | post-therapy sample | pool |
1 | 19/F | SAA | n | PB BM |
y y |
n n |
I I |
2 | 57/M | vSAA | n | PB BM |
y y |
n n |
I I |
3 | 40/F | SAA | n | PB BM |
y y |
n n |
I I |
4 | 70/F | SAA | n | PB BM |
y y |
n n |
I I |
5 | 64/M | SAA | n | PB BM |
y y |
y y |
IIa/IIb IIa/IIb |
6 | 70/F | vSAA | n | PB BM |
y y |
y y |
IIa/IIb IIa/IIb |
Abbreviations: F = female; M = male; (v)SAA = (very) severe aplastic anemia; n = no; y = yes; PB = peripheral blood; BM = bone marrow; I = pool I at initial presentation (n = 4); IIa = pool II at initial presentation (n = 2); IIb = pool II in hematological remission (n = 2). Disease classification was performed according to the International Study of Aplastic Anemia and Agranulocytosis [45].