Fig. 1.

Ribbon diagram of the FIII9–10 domain pair. Atomic coordinates were obtained from the Protein Data Bank (43) (Protein Data Bank code 1FNF) and imaged using RasTop (available on the World Wide Web at www.openrasmol.org). Residues substituted in this study, shown in their putative mutant conformation as rendered by Swiss PDB Viewer (available on the World Wide Web at spdbv.niehs.nih.gov), are displayed in ball-and-stick format and labeled accordingly using one-letter code. The dotted line designates disulfide bond present in oxidizing conditions. The synergistic PHSRN sequence and the RGD motif are indicated in yellow and blue, respectively.