Table 2.

Sex, age, and ethnicity (fixed effect) contributions to intersubject variation for 43 genes, in decreasing order of percentage of variance explained (equation 3).

		P Values for Effect							Fold Change Corresponding to Effect			Fold Change to Age Difference (69 vs. 23 years)Corresponding
Gene	Percent of Variance Explained by Sex, Age, and Ethnicity	Sex	Ethnicity	Sex + Ethnicity	Age	Sex + Age	Ethnicity + Age	Sex + Ethnicity + Age	WM vs. WF	HF vs. WF	HM vs. WF	WF	WM	HF	HM
NFKB1	27.90	0.0022	0.7083	0.1098	0.3335	0.0553	0.1896	0.2572	1.35	−1.04	−1.03	−1.29	−2.48	1.32	1.43
MPO	27.74	0.0128	0.0005	0.0116	0.2260	0.3535	0.8682	0.0909	1.42	1.82	1.31	1.57	1.00	1.43	4.48
IL18	27.46	0.0220	0.6228	0.9333	0.0119	0.0468	0.9150	0.1023	1.25	1.06	1.30	1.97	−1.02	1.88	2.77
MYC	26.91	0.0180	0.0132	0.7298	0.5240	0.1344	0.9658	0.1843	1.31	−1.42	−1.17	−1.21	−2.19	−1.24	1.23
TGFB1	25.88	0.0121	0.0726	0.5024	0.5696	0.0809	0.3451	0.1967	1.22	−1.18	−1.07	−1.13	−1.84	1.21	1.47
TNFSF6	23.90	0.0008	0.0344	0.0123	0.1039	0.0892	0.8499	0.4898	1.62	1.39	1.17	1.78	−1.28	1.61	1.32
LTA	23.87	0.0179	0.8223	0.0131	0.4992	0.1109	0.9253	0.4470	1.32	−1.03	−1.33	−1.22	−2.32	−1.17	−1.27
ELA2	23.65	0.3536	0.0013	0.0998	0.0262	0.2949	0.1695	0.0889	1.24	2.53	1.50	4.21	1.78	1.09	6.94
CD86	21.03	0.0289	0.2781	0.4782	0.1418	0.1509	0.3672	0.3403	1.24	1.13	1.23	1.47	−1.11	2.12	2.42
CD14	20.75	0.0066	0.9157	0.1150	0.1484	0.4972	0.0631	0.6869	1.42	−1.02	−1.05	−1.65	−2.24	1.64	1.71
C1QA	19.11	0.9650	0.2648	0.7856	0.0458	0.1489	0.0286	0.0015	1.01	1.25	1.15	2.51	1.07	−1.89	9.27
GCLC	19.04	0.1281	0.0510	0.4470	0.1961	0.5864	0.4943	0.1936	1.19	1.31	1.33	1.51	1.21	2.10	−1.66
HSPA1A	18.91	0.0208	0.3329	0.8448	0.2111	0.5560	0.1404	0.3747	1.37	−1.17	1.12	−1.58	−2.09	1.46	2.47
TNF	18.22	0.0489	0.6451	0.2638	0.6774	0.8716	0.0660	0.4877	1.44	−1.11	−1.14	−1.23	−1.11	3.34	1.59
HMGB1	17.72	0.0630	0.0047	0.1891	0.2164	0.3968	0.6109	0.9320	1.24	1.50	1.39	1.48	1.05	1.16	−1.31
CYBB	17.34	0.0223	0.9489	0.3272	0.9352	0.2462	0.1217	0.5252	1.31	−1.01	1.05	1.03	−1.56	2.17	2.22
SERPINA1	17.27	0.0730	0.2471	0.9965	0.2167	0.5933	0.0938	0.5365	1.28	−1.21	1.06	−1.59	−2.06	1.66	2.28
MMP9	16.14	0.1858	0.1057	0.3289	0.1730	0.6537	0.5372	0.3199	1.36	−1.57	1.34	−2.39	−3.46	−1.31	2.56
CXCL1	15.91	0.1965	0.1305	0.5228	0.3722	0.4229	0.1961	0.4267	1.18	−1.26	1.09	−1.36	−1.94	1.46	2.02
EGR1	15.53	0.0263	0.3387	0.4572	0.2550	0.0909	0.6418	0.2217	1.33	−1.15	−1.04	1.48	−1.44	1.16	1.54
IL15	15.44	0.4922	0.0501	0.0862	0.3364	0.9222	0.3302	0.2744	1.10	1.37	−1.03	1.42	1.36	2.45	−1.15
DPP4	15.00	0.2114	0.4354	0.4450	0.1223	0.6509	0.1781	0.5079	1.15	−1.11	−1.14	−1.63	−1.95	1.18	−1.70
CD4	14.86	0.0816	0.4197	0.3359	0.9445	0.0935	0.4285	0.4223	1.19	−1.10	−1.11	1.02	−1.77	1.42	1.34
HMOX1	14.81	0.0587	0.8654	0.6194	0.2167	0.0801	0.9441	0.0954	1.27	−1.03	1.10	1.53	−1.44	1.59	3.05
PLA2G7	14.20	0.0865	0.9282	0.7051	0.4431	0.8269	0.0575	0.6794	1.27	1.02	1.17	−1.34	−1.49	2.31	3.07
PLAUR	13.46	0.2046	0.4947	0.9590	0.4582	0.2254	0.6593	0.1645	1.17	−1.10	1.07	−1.28	−2.15	−1.02	1.83
TIMP1	13.33	0.0658	0.5106	0.2000	0.4669	0.1399	0.8392	0.3714	1.23	−1.09	−1.17	1.25	−1.44	1.37	1.51
CD8A	13.23	0.0412	0.1604	0.8832	0.2939	0.7299	0.4394	0.8534	1.30	1.24	1.56	−1.44	−1.24	1.05	1.44
ADAM17	12.71	0.1919	0.8616	0.6441	0.1633	0.2687	0.7874	0.7724	1.15	1.02	1.29	1.49	−1.01	1.68	1.37
PTPRC	12.65	0.0279	0.7490	0.7072	0.5853	0.4100	0.2291	0.5759	1.24	1.04	1.20	−1.15	−1.53	1.41	1.53
PTGS2	12.55	0.0630	0.9846	0.6788	0.0812	0.9289	0.1552	0.9724	1.28	−1.00	1.15	−1.87	−1.79	1.17	1.18
IL1RN	12.41	0.3848	0.0842	0.1495	0.1451	0.6460	0.1061	0.8547	−1.13	−1.33	−1.03	−1.73	−1.38	1.48	2.18
ICAM1	11.99	0.2755	0.2793	0.7173	0.4375	0.4882	0.2839	0.3328	1.13	−1.16	1.06	−1.27	−1.68	1.31	2.10
APAF1	11.91	0.0852	0.8732	0.8466	0.8508	0.4636	0.0957	0.6159	1.20	−1.02	1.13	−1.05	−1.38	1.96	1.06
MNDA	11.64	0.0662	0.9441	0.3044	0.5092	0.6863	0.3526	0.3483	1.24	−1.01	−1.03	−1.23	−1.46	1.28	2.29
IL18BP	10.94	0.1220	0.0913	0.1308	0.6556	0.3362	0.4393	0.4857	1.14	1.18	1.06	1.11	−1.20	1.45	1.62
SERPING1	10.70	0.4339	0.2313	0.9868	0.5224	0.9825	0.7008	0.2993	−1.21	−1.41	−1.69	−1.52	−1.49	−1.03	5.36
IL1R1	10.49	0.1039	0.7632	0.9654	0.7602	0.3975	0.2078	0.9550	1.34	−1.07	1.28	−1.16	−2.00	2.25	1.40
IL1B	10.09	0.6746	0.3584	0.4113	0.3254	0.7338	0.1561	0.9919	−1.07	−1.19	1.01	−1.52	−1.84	1.68	1.40
TLR2	9.82	0.2787	0.6278	0.5153	0.7197	0.1332	0.2841	0.8863	1.15	1.08	1.06	1.14	−1.77	2.05	1.16
TNFSF5	9.48	0.3867	0.3648	0.1478	0.0599	0.4390	0.3545	0.6951	1.12	1.16	−1.12	−2.01	−1.39	−1.19	−1.18
IFI16	6.46	0.5860	0.6442	0.5085	0.2437	0.8924	0.4439	0.9634	1.09	1.09	−1.02	−1.62	−1.74	1.00	−1.02
CD19	5.24	0.1827	0.4304	0.1925	0.3513	0.1437	0.4404	0.5098	1.23	1.16	−1.03	1.48	−1.51	−1.11	−1.25

Values were computed only for white and Hispanic subjects for whom sex and age were recorded (n = 68). Unadjusted P values are shown for each effect, including interaction terms, and underlined (together with corresponding fold changes) when < 0.05. Fold changes for sex and ethnicity effects are computed by raising 2 to the power of the corresponding ΔC_T effect terms; for age effects, they are computed by multiplying the corresponding slope effect by the range of ages in the sample (69 - 23) and then exponentiating. HF indicates Hispanic female; HM, Hispanic male; WF, white female; WM, white male.