Transcribed sequences in the region of the breakpoint. (A) Location of PAC clones used for exon trapping experiments. The breakpoint is indicated with a downward arrow. The locations of PAC clones (1125/D11, 1144/L2, 1019/P11, and 990/K20) and probes (JJ1, JJ2) are shown. (B) Transcribed sequences from the derivative 21 chromosome. Solid black box, exon-trapping clone; cross-hatched box, cluster of 12 overlapping EST clones (see text); checked box, TCRA enhancer.