Table 1.

Distributions of parameters used for Latin hypercube sampling

Parameter	Description	Minimum	Peak	Maximum
i0	Initial copy number	1		30
N	Population size	1,000		1,000,000
R0,0	Basic reproductive value	1		10
ν	Progression rate	0.0026		0.0053
p	Immediate progression	0	0.05	0.3
μ	Nondisease death rate	0.0133		0.04
μT	Disease death rate	0.0580	0.139	0.461
φ	Recovery rate	0.021	0.058	0.086
h	Horizontal transfer rate	0		0.001
ω1	Transposition rate	0.005		0.02
γ	Copy increase	0.4		0.65
c	Cost per element	0		0.002

The parameters i₀ and N were chosen from discrete uniform distributions; p, μ_T, and φ had triangular distributions (described in text: see Eq. 6); the remainder were chosen from continuous uniform distributions.