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. 1982 Jul;57(7):503–506. doi: 10.1136/adc.57.7.503

Fat as an energy supplement for preterm infants.

O J Hanmer, W T Houlsby, H Thom, I S Ross, D J Lloyd, G Russell
PMCID: PMC1627705  PMID: 6896624

Abstract

The absorption and utilisation of dietary fat as an energy supplement was studied in 15 healthy preterm infants. They were given two formulae for periods of one week. The standard low solute feed supplied 6 g fat and 476 kJ (114 cal) per kg. The high energy feed supplied 10 g of the same fat and 623 kJ (149 cal) per kg. Fat supplementation resulted in increased absorption (significantly higher chylomicron levels) without steatorrhoea or metabolic disturbance, apparently unchanged differential absorption of fatty acids, and a significantly higher rate of weight gain (mean 25.9 +/- 4.6 compared with 20.3 +/- 4.4 g/24 h). A high energy formula prepared with supplements of complex dietary fat is therefore of potential value in ensuring the adequate nutrition and growth of preterm infants.

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Selected References

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  1. BARON D. N., ECONOMIDIS J. THIN-LAYER CHROMATOGRAPHY FOR AMINO-ACIDS AND SUGARS. J Clin Pathol. 1963 Sep;16:484–486. doi: 10.1136/jcp.16.5.484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brooke O. G. Energy balance and metabolic rate in preterm infants fed with standard and high-energy formulas. Br J Nutr. 1980 Jul;44(1):13–23. doi: 10.1079/bjn19800005. [DOI] [PubMed] [Google Scholar]
  3. FERNANDES J., van de KAMER J. H., WEIJERS H. A. Differences in absorption of the various fatty acids studied in children with steatorrhea. J Clin Invest. 1962 Mar;41:488–494. doi: 10.1172/JCI104502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fomon S. J., Ziegler E. E., Thomas L. N., Jensen R. L., Filer L. J., Jr Excretion of fat by normal full-term infants fed various milks and formulas. Am J Clin Nutr. 1970 Oct;23(10):1299–1313. doi: 10.1093/ajcn/23.10.1299. [DOI] [PubMed] [Google Scholar]
  5. GOMPERTZ S. M., SAMMONS H. G. THE ORIGIN OF FAECAL LIPIDS. THE COMPOSITION OF FAECAL FATSIN HUMAN SUBJECTS. Clin Chim Acta. 1963 Jul;8:591–603. doi: 10.1016/0009-8981(63)90110-4. [DOI] [PubMed] [Google Scholar]
  6. Hamosh M., Sivasubramanian K. N., Salzman-Mann C., Hamosh P. Fat digestion in the stomach of premature infants. I. Characteristics of lipase activity. J Pediatr. 1978 Oct;93(4):674–679. doi: 10.1016/s0022-3476(78)80915-9. [DOI] [PubMed] [Google Scholar]
  7. Katz L., Hamilton J. R. Fat absorption in infants of birth weight less than 1,300 gm. J Pediatr. 1974 Nov;85(5):608–614. doi: 10.1016/s0022-3476(74)80501-9. [DOI] [PubMed] [Google Scholar]
  8. MATTSON F. H., VOLPENHEIN R. A. THE DIGESTION AND ABSORPTION OF TRIGLYCERIDES. J Biol Chem. 1964 Sep;239:2772–2777. [PubMed] [Google Scholar]
  9. MORALES S., CHUNG A. W., LEWIS J. M., MESSINA A., HOLT L. E., Jr Absorption of fat and vitamin A in premature infants; effect of different levels of fat intake on the retention of fat and vitamin A. Pediatrics. 1950 Jul;6(1):86–92. [PubMed] [Google Scholar]
  10. Matthys F., Christophe A., Verdonk G. A combined thin layer-gas chromatographic method for the analysis of fatty acid-containing stool fractions. Clin Chim Acta. 1972 Feb;36(2):341–350. doi: 10.1016/0009-8981(72)90007-1. [DOI] [PubMed] [Google Scholar]
  11. Norman A., Strandvik B., Ojamäe O. Bile acids and pancreatic enzymes during absorption in the newborn. Acta Paediatr Scand. 1972 Sep;61(5):571–576. doi: 10.1111/j.1651-2227.1972.tb15947.x. [DOI] [PubMed] [Google Scholar]
  12. Ockner R. K., Manning J. A. Fatty acid-binding protein in small intestine. Identification, isolation, and evidence for its role in cellular fatty acid transport. J Clin Invest. 1974 Aug;54(2):326–338. doi: 10.1172/JCI107768. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Shaw J. C. Evidence for defective skeletal mineralization in low-birthweight infants: the absorption of calcium and fat. Pediatrics. 1976 Jan;57(1):16–25. [PubMed] [Google Scholar]
  14. Signer E., Murphy G. M., Edkins S., Anderson C. M. Role of bile salts in fat malabsorption of premature infants. Arch Dis Child. 1974 Mar;49(3):174–180. doi: 10.1136/adc.49.3.174. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Southgate D. A., Widdowson E. M., Smits B. J., Cooke W. T., Walker C. H., Mathers N. P. Absorption and excretion of calcium and fat by young infants. Lancet. 1969 Mar 8;1(7593):487–489. doi: 10.1016/s0140-6736(69)91589-x. [DOI] [PubMed] [Google Scholar]
  16. Tomarelli R. M., Meyer B. J., Weaber J. R., Bernhart F. W. Effect of positional distribution on the absorption of the fatty acids of human milk and infant formulas. J Nutr. 1968 Aug;95(4):583–590. doi: 10.1093/jn/95.4.583. [DOI] [PubMed] [Google Scholar]
  17. Tomaszewski L. A new convenient, rapid and accurate method for determination of total lipids in feces. Clin Chim Acta. 1975 Jun 2;61(2):113–120. doi: 10.1016/0009-8981(75)90304-6. [DOI] [PubMed] [Google Scholar]
  18. Watkins J. B. Mechanisms of fat absorption and the development of gastrointestinal function. Pediatr Clin North Am. 1975 Nov;22(4):721–730. doi: 10.1016/s0031-3955(16)33203-5. [DOI] [PubMed] [Google Scholar]
  19. Watkins J. B., Szczepanik P., Gould J. B., Klein P., Lester R. Bile salt metabolism in the human premature infant. Preliminary observations of pool size and synthesis rate following prenatal administration of dexamethasone and phenobarbital. Gastroenterology. 1975 Sep;69(3):706–713. [PubMed] [Google Scholar]

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