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IKSO in rat cultured CGNs is inhibited by extracellular acidification. (a) IKSO current recorded as in Fig. 1a is inhibited by changing external pH from 7.4 to 6.4. (b) Block and washout of block by pH 6.4 external solution (control pH 7.4) is illustrated by measuring the standing-outward current at −20 mV. (c) Current-clamp recordings show depolarization of a CGN after extracellular acidification.
