Figure 3.

TASK-1 expressed in oocytes shares properties of IK_SO that is present in cerebellar slices. (a) TASK-1 currents expressed in oocytes and recorded by stepping to −80 mV for 500 ms once every 10 s from a holding potential of −20 mV have the same current profile as IK_SO and are blocked by extracellular acidification and by carbachol. Block by extracellular acidification and carbachol (100 μM) is illustrated (Lower) by measuring the standing-outward current at −20 mV. (b) IK_SO, recorded from CGNs in mouse cerebellar slices, was determined by the same voltage protocol described for a. Block by 1 mM Ba²⁺ is illustrated (Lower) by measuring the standing-outward current at −20 mV. (c) Ba²⁺ sensitivity of TASK-1 in oocytes and IK_SO in cerebellar slices.