Fig. 2.

MrVIB reduces allodynic and hyperalgesic behavior in neuropathic and inflammatory pain models. Shown are time plots of the effect of MrVIB (for clarity only 0.03, 0.3, and 3.0 nmol doses are shown; ●, □, and ■, respectively), or vehicle (○) on mechanical paw withdrawal threshold (PWT) (A and B). Thermal paw withdrawal latency (PWL) (C and D) in animals that had undergone partial ligation of the sciatic nerve (PNL) 14 days before the experiment (A and C), or complete Freund's adjuvant (CFA) injection into the plantar surface of the hindpaw 24 h before the experiment (B and D). The pre-PNL and pre-CFA mechanical PWT and thermal PWL are also shown (▾). Data are shown as the mean ± SEM. ∗ and + denote P < 0.05 for 0.3 and 3 nmol compared with time 0, respectively.