Fig. 3.

MrVIB reduces allodynia and hyperalgesia at doses below those producing motor disruption. Dose–response curves were determined from area under time-response curves [AUC calculated by using the preinjection response (−0.5 h) as shown in Fig. 2 as a baseline for integration; same scales for A–D]. The effects of MrVIB (A and B) and lignocaine (C and D) on mechanical PWT (○), thermal PWL (●), and rotarod latency (■) in animals that had undergone PNL (A and C) or CFA injection (B and D). Logistic functions were fit to determine ED₅₀s. Data are shown as the mean ± SEM. ∗, +, and # denote P < 0.05 for mechanical PWT, thermal PWL, and rotarod latency compared with control, respectively. AUCs for PWT, PWL, and rotarod responses to saline are shown to the left of the abscissa.