Figure 4.

Status epilepticus (SE) is followed by down-regulation of GluR2 but not GluR1 immunolabeling in CA3a pyramidal neurons. Presentation as in Fig. 3. GluR1 and GluR2 immunoreactivity in sections from a saline-injected control (A and C) and an animal 22 h after KA injection (B and D). GluR2 immunoreactivity decreased in pyramidal cells after KA administration (B), although GluR1 immunoreactivity was unchanged (D). (E and F) Superposition of images of GluR1 and GluR2 labeling show colocalization. (Scale bar, 50 μm.) so, stratum oriens; sp, stratum pyramidale; slu, stratum lucidum.