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. 2000 Mar 14;97(7):3643–3648. doi: 10.1073/pnas.050582497

Figure 2.

Figure 2

L248Tα7 expresses functional nAcChoRs in Bosc 23 cells. (A) Typical whole-cell currents elicited by the agonists indicated. Horizontal bars represent timing of drug applications. Holding potential = −50 mV. (B) AcCho (●; eight cells) and nicotine (○; eight cells) dose-response relationships. Solid lines show fitted Hill equations, and parameters are reported in Table 1. Peak currents were normalized to those evoked by 0.5 μM AcCho (0.76 ± 0.30 nA) or 5 μM nicotine (0.72 ± 0.17 nA). (C) Averaged I–V ramp (duration 0.5 s) from five cells, during sustained responses to nicotine (100 nM). Note marked current rectification at positive potentials.