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. 2006 Jul 17;149(1):100–109. doi: 10.1038/sj.bjp.0706832

Table 1.

Relaxations induced by PACAP 38, PACAP 27, VIP and [Ala11,22,28]-VIP in pig urinary bladder neck

Agonist n pD2 Emax (%)
PACAP 38
7
7.0±0.1
78.4±8.6
PACAP 27
9
7.2±0.1
69.9±4.7
VIP
12
7.0±0.2
80.1±7.4
[Ala11,22,28]-VIP 6 6.9±0.1 36.3±9.3a,b,c

Results are expressed as mean±s.e.m. of n experiments. Differences were analysed by one-way ANOVA followed by an a posteriori Bonferroni t-test in case of significance.

a,b,c

Significantly (P<0.05) different compared to the PACAP 38, PACAP 27 and VIP values. Emax is the maximal relaxation, expressed as a percentage of the PhE-induced contraction, obtained for each drug. pD2=−log EC50, where EC50 is the concentration of agonist producing 50% of the Emax.