Table 1.
Agonist | n | pD2 | Emax (%) |
---|---|---|---|
PACAP 38 |
7 |
7.0±0.1 |
78.4±8.6 |
PACAP 27 |
9 |
7.2±0.1 |
69.9±4.7 |
VIP |
12 |
7.0±0.2 |
80.1±7.4 |
[Ala11,22,28]-VIP | 6 | 6.9±0.1 | 36.3±9.3a,b,c |
Results are expressed as mean±s.e.m. of n experiments. Differences were analysed by one-way ANOVA followed by an a posteriori Bonferroni t-test in case of significance.
Significantly (P<0.05) different compared to the PACAP 38, PACAP 27 and VIP values. Emax is the maximal relaxation, expressed as a percentage of the PhE-induced contraction, obtained for each drug. pD2=−log EC50, where EC50 is the concentration of agonist producing 50% of the Emax.