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. 2006 Jul 17;149(1):65–72. doi: 10.1038/sj.bjp.0706826

Figure 3.

Figure 3

Effect of the COX inhibitor dexketoprofen (DKT) on ATRA-mediated sensitization. The it. administration of 6 μg of DKT 10 min before administration of 10 ng of ATRA fully blocked the effect induced by ATRA. The same dose of DKT did not modify the nociceptive responses when injected alone. The results confirm that the effect of ATRA is mediated by a modulation of the COX activity within the spinal cord. The administration of DKT vehicle did not modify ATRA activity. Statistical comparison and layout as for Figure 1.