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. 2006 Jul 17;149(1):65–72. doi: 10.1038/sj.bjp.0706826

Figure 4.

Figure 4

Effect of IL-1ra on ATRA-mediated sensitization. The it. administration of 10 μg of the IL-1β antagonist (IL-1ra) 15 min after the administration of ATRA fully reversed the effect of ATRA, indicating that the sensitization induced by ATRA was not only mediated by COX activity but also by the IL-1 system. The same amount of the antagonist did not cause any effect on the withdrawal responses when injected alone. In addition, the administration of IL-1ra vehicle did not modify ATRA activity. Statistical comparison and layout as for Figure 1.