Table 1.

Distribution of radioactivity from ¹²⁵I-TFF3, given i.v., to the main target tissues 15 and 180 min after injection to mice

	Blood	Kidney	GI tract	Stomach	Gll. Man.a	Thyroids
125I-mTFF3 15 min	35 (29, 41)	18 (11, 26)	14 (13, 15)	4.7 (4.0, 5.0)	0.5 (0.3, 0.6)	0.2 (0.1, 0.2)
125I-hTFF3 15 min	34 (22, 45)	20 (12, 27)	15 (13, 18)	4.9 (3.9, 5.9)	0.5 (0.4, 0.6)	0.2 (0.1, 0.2)
125I-mTFF3 180 min	16 (13, 19)	8.1 (6.4, 10)	7.8 (6.8, 8.8)	4.2 (3.5, 4.8)	4.2 (3.1, 5.2)	2.6 (1.4, 3.8)
125I-hTFF3 180 min	24 (16, 32)*	2.5 (1.6, 3.4)***	13 (9.8, 16)**	6.9 (4.8, 8.9)*	4.4 (3.1, 5.7)	1.6 (0.9, 2.2)

Abbreviations: CI, confidence intervals; GI, gastrointestinal; i.v., intravenously; TFF, trefoil factor family.

Mice (n=8 per group) were injected i.v. with either ¹²⁵I-mTFF3 or ¹²⁵I-hTFF3 (300 000 c.p.m.). After 15 or 180 min, the animals were killed and the radioactivity in a blood sample and in various tissues was measured in a gamma-counter. The values are presented as the mean percentage of injected dose with 95% CIs in parentheses. ^* mTFF3 vs hTFF3. ^*P<0.05. ^**P<0.01, ^***P<0.0001.

^aMandibular glands.