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. 2000 Mar 28;97(7):3678–3683. doi: 10.1073/pnas.97.7.3678

Figure 5.

Figure 5

Western blot analysis in nuclear extracts from hearts treated with 100 μM of scrambled peptide or PAR-2AP at 5 min of baseline, at 20 min of global ischemia, and at 60 min of reperfusion period normalized by γ-tubulin. After 20 min of ischemia, there was a marked increase in TNFα. PAR-2 expression increased after PAR-2AP treatment only. However, at 60 min of reperfusion, we observed a little increase in PAR-2 and TNFα expression in hearts treated with the scrambled peptide whereas hearts treated with PAR-2AP showed a marked increase of PAR-2 and TNFα expression.