Table 1.
Coronary flow, ml/min/g tissue wet weight | Control | 100 μM Scrambled peptide | 100 μM PAR-2AP | 100 μM PAR-2AP + Genistein |
---|---|---|---|---|
20 min Baseline | 13.5 ± 1.2 | 13.6 ± 1.1 | 13.2 ± 1.3 | 13.0 ± 1.4 |
20 min Isch | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 |
5 min Rep | 6.5 ± 1.6 | 6.6 ± 1.8 | 7.2 ± 1.7 | 7.4 ± 1.9 |
60 min Rep | 9.1 ± 1.4 | 9.2 ± 1.5 | 10.9 ± 1.6* | 10.8 ± 1.5* |
Heart Rate, beats/min | ||||
20 min Baseline | 247 ± 20 | 248 ± 22 | 247 ± 24 | 249 ± 23 |
5 min Rep | 127 ± 29 | 128 ± 28 | 122 ± 28 | 120 ± 25 |
60 min Rep | 192 ± 26 | 191 ± 27 | 210 ± 28 | 200 ± 26 |
*, P < 0.05 vs. control and scrambled peptide-treated group. Mean ± SD, n = 6 for each group.