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Potency of various PDE inhibitors on human PDE11A1
| Inhibitor | Selective for PDE type | IC50, μM | PDE11A1 IC50, μM |
|---|---|---|---|
| IBMX | Nonselective | 2–59 | 49.8 |
| Milrinone | PDE3 | 1.3 | >100 |
| Rolipram | PDE4 | 2.0 | >100 |
| Zaprinast | PDE1/5/6 | 6.9/0.76/0.15 | 12.0 |
| Dipyridamole | PDE5/6/9/10 | 0.9/0.38/4.5/1.1 | 0.37 |
