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. 2006 Nov 3;2(11):e150. doi: 10.1371/journal.pcbi.0020150

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© 2006 Bush and Lahn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) An example of an iso GC/dinucleotide group in 4-bp words. This group consists of the tetranucleotides TGAC, TGTC, and TCAC. In addition to having the same GC content, these words (considering also their reverse complements which are written below them) share the same six dinucleotides. The dinucleotide composition of each word is written below it with lines showing that the same dinucleotides are present in all three words.

(B) An example of an iso GC/di/tetranucleotide group in 8-bp words. The two words CAAGTTGC and CAACTTGC have the same GC content as well as sharing the same 14 dinucleotides and the same 10 tetranucleotides.