Table 1.
Tumor incidence and phenotype in NRL-PRL virgin female mice
| Lineage | Tumor incidence | Mean tumor latency ±s.d.1(months) | Tumor histotypes2(number/all tumors3) |
|---|---|---|---|
| 1647-13 | 15/234 (65%) | 16.7±4.1 | Papillary (10/23; 44%)
Glandular (5/23; 22%) Solid (5/23; 22%) Adenosquamous (1/23; 4%) Fibroadenocarcinoma (1/23; 4%) Carcinosarcoma (1/23; 4%) |
| 1655-8 | 12/154 (80%) | 15.5±2.3 | Papillary (5/16; 31%)
Glandular (3/16; 19%) Solid (1/16; 6%) Adenosquamous (6/16; 37%) Fibroadenocarcinoma (1/16; 6%) |
| Nontransgenic FVB/N5 | 3/61 (5%) | 18.8±5.3 | Fibrosarcoma (1/3; 33%)
Glanular (1/3; 33%) Adenosquamous (1/3; 33%) |
1
Latency of tumor growth to 1.5 cm;
2
Many neoplasms displayed a mixed phenotype; only the dominant phenotype is noted using the classifications described (Cardiff et al., 2000). Except for the noted exceptions, all were adenocarcinomas or carcinomas;
3
More than one tumor was present in several individuals;
4
Total females for each genotype include all those in the colony ⩾19 months of age;
5