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SOS2 encodes a putative serine/threonine protein kinase. (A) Diagrammatic representation of SOS2 structure. (B) SOS2 cDNA sequence and the conceptual translational product of its longest ORF (GenBank accession number AF237670). Underlined is a stop codon (TAA) at −6 to −4 that precedes the ATG in-frame. Numbers I–XI indicate kinase subdomains as defined by Hanks et al. (25), with invariant and nearly invariant amino acid residues highlighted in black and gray, respectively.
