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. 1999 Apr 13;96(8):4307–4312. doi: 10.1073/pnas.96.8.4307

Figure 1.

Figure 1

Sequence and structure of DRONC. (A) Deduced amino acid sequence of DRONC. The full-length nucleotide sequence of dronc cDNA comprises 2,090 bp. dronc ORF extends from base 370 to base 1722 (450 aa). The catalytic Cys residue is underlined. (B) Putative structure of DRONC. The potential cleavage sites (D113, D135, and D324) in the DRONC precursor are indicated. The position of pentapeptide sequence PFCRG containing the catalytic Cys residue is shown as a hatched box. (C) An alignment of the CARDs of various caspases. The locations of the six α-helices (H1-H6) are marked. Residues conserved in at least four proteins are marked in black, those conserved in three proteins are highlighted in dark gray and those showing conservative changes are shown in light gray. Note that the DRONC CARD contains an extended linker region between H3 and H4, not present in other CARDs.