Abstract
The effects of pentazocine on colonic motor activity were studied in five normal subjects, five patients with irritable bowel syndrome, and five patients with diverticular disease. The drug decreased intraluminal colonic pressures in all patients but one. Since morphine, which increases intraluminal colonic pressures, is contraindicated in patients with abdominal pain of colonic origin (diverticular disease, irritable bowel syndrome), we suggest that pentazocine may be a useful drug in such cases.
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Selected References
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- ARCHER S., ALBERTSON N. F., HARRIS L. S., PIERSON A. K., BIRD J. G. PENTAZOCINE. STRONG ANALGESICS AND ANALGESIC ANTAGONISTS IN THE BENZOMORPHAN SERIES. J Med Chem. 1964 Mar;7:123–127. doi: 10.1021/jm00332a001. [DOI] [PubMed] [Google Scholar]
- Danhof I. E., Blackmore W. P. Mechanism of action of pentazocine on gastrointestinal motor function. Toxicol Appl Pharmacol. 1967 Mar;10(2):223–232. doi: 10.1016/0041-008x(67)90105-6. [DOI] [PubMed] [Google Scholar]
- Danhof I. E., Blackmore W. P., Upton G. L. Effect of pentazocine on gastric emptying and small intestinal propulsive motility in the rat. Toxicol Appl Pharmacol. 1966 Sep;9(2):356–362. doi: 10.1016/0041-008x(66)90132-3. [DOI] [PubMed] [Google Scholar]
- HARRIS L. S., PIERSON A. K. SOME NARCOTIC ANTAGONISTS IN THE BENZOMORPHAN SERIES. J Pharmacol Exp Ther. 1964 Feb;143:141–148. [PubMed] [Google Scholar]
- KEATS A. S., TELFORD J. STUDIES OF ANALGESIC DRUGS. VIII. A NARCOTIC ANTAGONIST ANALGESIC WITHOUT PSYCHOTOMIMETIC EFFECTS. J Pharmacol Exp Ther. 1964 Feb;143:157–164. [PubMed] [Google Scholar]
- PAINTER N. S., TRUELOVE S. C. THE INTRALUMINAL PRESSURE PATTERNS IN DIVERTICULOSIS OF THE COLON. I. RESTING PATTERNS OF PRESSURE. II. THE EFFECT OF MORPHINE. Gut. 1964 Jun;5:201–213. doi: 10.1136/gut.5.3.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SADOVE M., BALAGOT R. C., PECORA F. N. PENTAZOCINE--A NEW NONADDICTING ANALGESIC. PRELIMINARY SINGLE-BLIND STUDY. JAMA. 1964 Jul 20;189:199–202. [PubMed] [Google Scholar]