Table 1.
Inflammatory response in the lungs of wild-type (WT) and interleukin-1 receptor 1 knockout (IL-1R−/−) mice (n = 6–10/group) infected with Histoplasma capsulatum.
| Day of infection, organ, mouse type | Cell type |
|||
|---|---|---|---|---|
| CD4+ | CD8+ | Gr-1+ | Mac-3+ | |
| Day 1 | ||||
| Lung | ||||
| WT | 0.6 ± 0.2 | 0.4 ± 0.1 | 6.2 ± 1.8 | 1.4 ± 0.2 |
| IL-1R−/− | 0.4 ± 0.2 | 0.3 ± 0.1 | 2.6 ± 0.3a | 1.3 ± 0.1 |
| Spleen | ||||
| WT | 28.4 ± 2.3 | 13.6 ± 0.9 | 8.4 ± 0.5 | 5.9 ± 0.4 |
| IL-1R−/− | 24.6 ± 2.3 | 13.1 ± 1.0 | 8.5 ± 0.2 | 5.4 ± 0.2 |
| Day 3 | ||||
| Lung | ||||
| WT | 2.1 ± 0.4 | 1.7 ± 0.3 | 4.6 ± 0.9 | 0.6 ± 0.1 |
| IL-1R−/− | 2.7 ± 0.6 | 2.1 ± 0.6 | 2.4 ± 0.5 | 0.4 ± 0.1 |
| Spleen | ||||
| WT | 20.9 ± 3.3 | 14.6 ± 1.3 | 12.4 ± 2.3 | 3.3 ± 0.5 |
| IL-1R−/− | 33.6 ± 3.8 | 17.3 ± 1.4 | 14.2 ± 0.6 | 2.6 ± 0.5 |
| Day 7 | ||||
| Lung | ||||
| WT | 7.8 ± 1.1 | 3.5 ± 0.9 | 13.1 ± 2.0 | 1.7 ± 0.4 |
| IL-1R−/− | 3.9 ± 0.8a | 2.5 ± 0.6 | 13.0 ± 2.5 | 2.8 ± 0.8 |
| Spleen | ||||
| WT | 36.0 ± 1.9 | 11.7 ± 1.0 | 13.8 ± 1.6 | 0.7 ± 0.1 |
| IL-1R−/− | 42.7 ± 3.6 | 16.0 ± 1.4 | 16.5 ± 1.8 | 0.3 ± 0.1 |
NOTE. Data are mean ± SE no. (105) of inflammatory cells and are pooled from 2 experiments.
a
P<.01, compared with the response in WT mice (analysis of variance).