Skip to main content
. 2006 Nov 7;4(11):e369. doi: 10.1371/journal.pbio.0040369

Figure 5. Thermoneutral and Cold-Adapted PGC1βKO Mice Display Reduced Resting and NE-Stimulated Energy Expenditure.

Figure 5

Male WT and PGC1βKO mice were acclimatised to 30 °C or 4 °C as stated in the Materials and Methods.

(A) Oxygen consumption per mouse (ml/min). Similar results were obtained when the data were standardised using the body weight (kg)0.75 scaling; WT, black bars; PGC1βKO, white bars.

(B) RER. Solid circles, WT at 4 °C; open circles; PGC1βKO at 4 °C; solid squares, WT at 30 °C; open squares, PGC1βKO at 30 °C.

(C) Oxygen consumption per mouse (ml/min) measured post-administration of 1 mg/kg norepinephrine.

(D) BAT mRNA expression in thermoneutral and cold-adapted mice. WT thermoneutral, black bars; PGC1βKO thermoneutral, white bars; WT cold-adapted, dark gray bars; PGC1βKO cold-adapted, light gray bars. Individual measurements are standardized using 36B4 and the average of the WT, thermoneutral group was set to 1. n = 4–5 mice per genotype per condition for each experiment. * indicate a significant difference between cold-adapted WT and PGC1βKO mice. ## indicates a significant difference between thermoneutral WT and PGC1βKO mice.