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. 2006 Nov 7;4(11):e369. doi: 10.1371/journal.pbio.0040369

Figure 8. PGC1βKO Hearts Display a Blunted Heart Rate Response to Dobutamine Stimulation In Vivo.

Figure 8

PGC1βKO and WT littermates (male, 26-wk-old) were treated as stated in Material and Methods and infused with 10 or 40 ng/min/g BW dobutamine to measure in vivo hemodynamic responses WT, solid line; KO, dashed line.

(A) Percentage change in heart rate from basal during dobutamine infusion.

(B and C) Measurement of ventricular performance, dP/dt, during infusion. The arrow marks the increase in dobutamine concentration in the infusion from 10 to 40 ng/min/g BW. n = 5 mice per genotype.