Table 3.
Mean log antibody measure (and standard error) for human herpesviruses 1–6 according to age at diagnosis, sex and other socio-demographic factors.
| Risk factor | Virus | ||||||
| HSV-1 | HSV-2 | VZV | EBV-EBNA | CMV | HHV-6 | ||
| Age | <20 | 1.55 (0.11) | -0.19 (0.20) | 1.06 (0.12) | 1.52 (0.15) | 1.79 (0.21) | 0.64 (0.15) |
| 20–39 | 1.61 (0.04) | 0.25 (0.08) | 1.06 (0.05) | 1.44 (0.07) | 2.19 (0.12) | 0.70 (0.06) | |
| 40–59 | 1.61 (0.04) | 0.36 (0.07) | 1.07 (0.05) | 1.40 (0.07) | 2.26 (0.07) | 0.74 (0.06) | |
| 60+ | 1.60 (0.05) | 0.48 (0.08) | 1.11 (0.06) | 1.47 (0.07) | 2.41 (0.09) | 0.66 (0.05) | |
| p-value | 0.92 | 0.003 | 0.41 | 0.77 | 0.006 | 0.52 | |
| Sex | Males | 1.59 (0.05) | 0.05 (0.08) | 1.03 (0.06) | 1.43 (0.07) | 1.98 (0.09) | 0.59 (0.06) |
| Females | 1.60 (0.05) | 0.40 (0.08) | 1.11 (0.06) | 1.48 (0.07) | 2.34 (0.10) | 0.78 (0.06) | |
| p-value | 0.91 | <0.0001 | 0.09 | 0.44 | <0.0001 | 0.0002 | |
| Smoking | Never | 1.60 (0.04) | 0.21 (0.08) | 1.03 (0.05) | 1.45 (0.07) | 2.16 (0.09) | 0.67 (0.06) |
| Ever | 1.59 (0.05) | 0.24 (0.09) | 1.11 (0.06) | 1.46 (0.08) | 2.17 (0.10) | 0.70 (0.06) | |
| p-value | 0.91 | 0.56 | 0.07 | 0.96 | 0.94 | 0.34 | |
| Education | < Grade 3 | 1.59 (0.05) | 0.30 (0.09) | 1.10 (0.06) | 1.41 (0.08) | 2.18 (0.10) | 0.74 (0.07) |
| Grade 3–7 | 1.64 (0.05) | 0.24 (0.08) | 1.09 (0.05) | 1.47 (0.07) | 2.13 (0.09) | 0.69 (0.06) | |
| Grade 8+ | 1.55 (0.05) | 0.14 (0.09) | 1.04 (0.06) | 1.49 (0.08) | 2.18 (0.10) | 0.64 (0.07) | |
| p-value | 0.53 | 0.09 | 0.26 | 0.18 | 0.99 | 0.14 | |
| Area of birth | Urban | 1.61 (0.05) | 0.28 (0.09) | 1.10 (0.06) | 1.46 (0.07) | 2.14 (0.10) | 0.70 (0.06) |
| Rural | 1.57 (0.04) | 0.18 (0.08) | 1.05 (0.05) | 1.45 (0.07) | 2.19 (0.09) | 0.67 (0.07) | |
| p-value | 0.29 | 0.13 | 0.16 | 0.67 | 0.48 | 0.45 | |
| Area living | Urban | 1.59 (0.04) | 0.19 (0.07) | 1.08 (0.05) | 1.45 (0.07) | 2.17 (0.09) | 0.71 (0.06) |
| Rural | 1.59 (0.05) | 0.27 (0.09) | 1.07 (0.06) | 1.46 (0.08) | 2.15 (0.11) | 0.67 (0.06) | |
| p-value | 0.99 | 0.35 | 0.83 | 0.76 | 0.85 | 0.53 | |
| HIV | +ve | 1.53 (0.06) | 0.27 (0.11) | 1.12 (0.07) | 1.43 (0.09) | 2.22 (0.12) | 0.71 (0.08) |
| -ve | 1.66 (0.04) | 0.18 (0.07) | 1.02 (0.05) | 1.48 (0.06) | 2.11 (0.08) | 0.67 (0.05) | |
| p-value | 0.03 | 0.35 | 0.10 | 0.52 | 0.34 | 0.66 | |
| No. of | 0–2 | 1.60 (0.05) | 0.12 (0.08) | 1.02 (0.06) | 1.47 (0.07) | 2.12 (0.09) | 0.64 (0.06) |
| sexual | 3–5 | 1.58 (0.05) | 0.25 (0.08) | 1.05 (0.06) | 1.41 (0.07) | 2.18 (0.09) | 0.75 (0.06) |
| partners | 6+ | 1.60 (0.05) | 0.31 (0.09) | 1.15 (0.06) | 1.49 (0.08) | 2.19 (0.11) | 0.67 (0.07) |
| p-value | 0.96 | 0.01 | 0.03 | 0.96 | 0.34 | 0.26 | |
| Marital | Single | 1.58 (0.04) | 0.06 (0.08) | 1.04 (0.05) | 1.45 (0.07) | 2.03 (0.09) | 0.65 (0.06) |
| status | Married | 1.62 (0.05) | 0.22 (0.08) | 1.11 (0.05) | 1.43 (0.07) | 2.16 (0.09) | 0.67 (0.06) |
| Widowed | 1.59 (0.06) | 0.20 (0.11) | 1.04 (0.07) | 1.41 (0.09) | 2.17 (0.12) | 0.66 (0.08) | |
| Separated | 1.58 (0.07) | 0.42 (0.12) | 1.10 (0.08) | 1.54 (0.10) | 2.29 (0.14) | 0.77 (0.09) | |
| p-value | 0.64 | 0.005 | 0.45 | 0.52 | 0.26 | 0.34 | |
Multivariate analysis of variance excluding patients with multiple myeloma and adjusted for all factors above plus disease group, plate and day of assay. P-values are for trend tests where appropriate and otherwise for heterogeneity.