Table 1.
Baseline subject characteristics
Characteristic | Subject |
||||
---|---|---|---|---|---|
1 | 2 | 3 | 4 | 5 | |
Age | 41 | 44 | 40 | 27 | 45 |
Gender | M | M | M | M | M |
Ethnic group | Caucasian | Caucasian | African American | African American | Caucasian |
Baseline viral load | 188,500 | 54,100 | 46,150 | 32,400 | 19,970 |
Baseline CD4 count per mm3 | 253 | 316 | 273 | 308 | 220 |
HIV infection, y | 15 | 15 | 15 | 10 | 9 |
Previous ARV experience | 4 NRTI, 2 NNRTI, 4 PI | 5 NRTI, 4 PI | 6 NRTI, 1 PI | 2 NRTI, 1 NNRTI, 1 PI | 5 NRTI, 1 NNRTI, 1 PI |
Therapy at enrollment | 1 NRTI, 2 PI | 3 NTRI, 1 NNRTI, 1 PI | None | 2 NRTI, 1 NNRTI | 2 NNRTI, 1 PI |
No. of VRX496 CD4 cells infused | 1 × 1010 | 1 × 1010 | 0.6 × 1010 | 1 × 1010 | 0.9 × 1010 |
CD3+ cells*, % | 95 | 100 | 80 | 98 | 94 |
Average vector copy no. per cell* | 2.3 | 1.8 | 1.0 | 4.1 | 1.2 |
p24 pg/ml* | <50 | <50 | <50 | <50 | <50 |
RCL | Negative | Negative | Negative | Negative | Negative |
NRTI, nucleoside reverse-transcriptase inhibitor; NNRTI, nonnucleoside reverse-transcriptase inhibitor; PI, protease inhibitor.
*Value determined at the time of cell harvest.