Table 1.
Comparison of intraperitoneal lethal doses (LD50) and body weights of control mice and those injected with phytol and PHIS-01.
| Test Adjuvants | Dose (μg) | Acute intoxication (% Survival in 24 h) | Mean body weight loss (%) | LD50 (mg/kg body weight) | |||
| Day 1 | Day 3 | Day 5 | Day 7 | ||||
| PBS (Control) | 250 (μl) | 100 | 3.1 | 0 | 0 | 0 | *ND |
| Phytol | 40 | 100 | 13.86 | 19.41 | 24.75 | 15.92 | >4 |
| 80 | 100 | 14.1 | 8.7 | 7.8 | All dead | ||
| 100 | 50 | 13.98 | 26.73 | All dead | |||
| PHIS-01 | 40 | 100 | 3.8 | 10.16 | 9.08 | 8.9 | >8 |
| 80 | 100 | 7.1 | 17.69 | 13.5 | 10.06 | ||
| 100 | 100 | 7.8 | 13.68 | 22.92 | 16.92 | ||
* Not detected