Figure 5.

Contours of the objective function, Φ($\overline{frap}$), in a) D_f - $K_a^{*}$, b) D_f - K_d, and c) $K_a^{*}$ - K_d planes for GFP-GR (Scenario A) in lower subspace of model parameters. The response surfaces were generated using a rectangular grid. The domain of each parameter was discretized into 100 discrete points resulting in 10000 grid points for each response surface plot. Intensity scale is the same as Figure 4.