Fig. 1.
The distance between optical map midpoints. The distance between maps M1N and M2N is given by the distance between map centers. In this case, dist(M1N, M2N) = dist(C1, C2) = (−1)I{u1≤C,1v2≥C2} × (A1 + (B1 + B2)/2 + E2), where u1 represents the closest to C1 matching site of the largest alignment block (u1, u2; v1, v2) that does not contain center points C1 and C2.