Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Nov 15;20(22):3130–3146. doi: 10.1101/gad.1478706

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, Cold Spring Harbor Laboratory Press

PMC Copyright notice

Figure 7. — Retention of epithelial differentiation in Smad4-deficient PDAC. (A) Western blot showing E-cadherin (top panel) and slug expression (middle panel) in PDAC cell lines from Cre LSL-Kras^G12D Ink4a/Arf^lox/lox Smad4^+/+ mice (lanes 1–5) and Cre LSL-Kras^G12D Ink4a/Arf^lox/lox Smad4^lox/lox (lanes 6–9) mice. (B) qRT–PCR for E-cadherin expression in primary PDAC from Cre LSL-Kras^G12D Ink4a/Arf^lox/⁺ Smad4^+/+ mice and Cre LSL-Kras^G12D Ink4a/Arf^lox/⁺ Smad4^lox/lox mice. (C) IHC analysis of S100A4 expression in PDAC from a Ptf1-Cre LSL-Kras^G12D Ink4a/Arf^lox/⁺ Smad4^+/+ mouse and a Ptf1-Cre LSL-Kras^G12D Ink4a/Arf^lox/⁺ Smad4^lox/lox mouse; note the staining of stromal fibroblasts in both genotypes (arrows) and staining of tumor glands in the Smad4^+/+ tumors but not those lacking Smad4 (asterisks).