TABLE 1.
Characteristics of the 157 children (67 girls, 90 boys) at sampling time
| Characteristic | Mean | SD | Median | Range |
|---|---|---|---|---|
| Age (yra) | 9.1 | 4.8 | 10.2 | 3 days-18 |
| BW (kg) | 29.0 | 14.9 | 27.6 | 2-73 |
| Dose (mg) | 279 | 102 | 266 | 30-532 |
| Dose (mg/kg) | 109 | 3.7 | 10.4 | 4.4-29.4 |
| Dose (mg/m2) | 288 | 66 | 281 | 124-566 |
| No. of LPVb mutationsc | 2.6 | 2 | 2 | 0-8 |
| VL (copies/ml)d | 288,327 | 373,695 | 116,500 | 160-1,600,000 |
| CD4 cellsc (no./mm3) | 462 | 520 | 300 | 6-2,476 |
| % CD4 cellsc | 14.7 | 10 | 13.5 | 1-42 |
| Lopinavir plasma concn (mg/liter) | 8.99 | 4.89 | 8.25 | 0.33-29.7 |
| No. of samples | 541 | |||
| No. of samples per patient | 3.5 | 3 | 1-14 |
a
Unless indicated otherwise.
b
LPV, lopinavir.
c
n = 69 patients.
d
VL, viral load. The results are for the 68 patients whose viral loads were >50 copies/ml.