TABLE 2.
Mediana MICs and mean ± standard deviation AUBCs for daptomycin alone and when coadministered with gentamicin against the tested microorganisms
| Isolateb | MIC (μg/ml)
|
AUBC (mean ± SD)
|
P valuec | ||
|---|---|---|---|---|---|
| Daptomycin | Gentamicin | Daptomycin | Daptomycin plus gentamicin | ||
| MRSA 494 | 0.25 | 0.5 | 1,263 ± 209 | 922 ± 142 | <0.001 |
| CA-MRSA 44 | 0.25 | 0.5 | 935 ± 122 | 902 ± 132 | 0.565 |
| MSSA 29213 | 0.5 | 0.5 | 1,067 ± 259 | 972 ± 193 | 0.432 |
| VSEF 49452 | 2 | 16 | 238 ± 65 | 213 ± 37 | 0.399 |
| VREF 80 | 2 | 32 | 36 ± 8 | 34 ± 7 | 0.283 |
| VSEF 29212 | 2 | 12 | 151 ± 27 | 156 ± 22 | 0.240 |
a
Median of 6 to 16 experiments.
b
MRSA, methicillin-resistant S. aureus; CA-MRSA, community-acquired MRSA; MSSA, methicillin-susceptible S. aureus; VSEF, vancomycin-susceptible E. faecalis; VREF, vancomycin-resistant E. faecium.
c
Data were log transformed before statistical comparison.