TABLE 3.

Comparative efficacies of 1% (wt/wt) retapamulin ointment, mupirocin (2% ointment), and fusidic acid (2% cream) following 4 days of treatment against surgical wound infections in mice caused by methicillin- and/or mupirocin-resistant S. aureus

S. aureus strain	Mupirocin MIC (mg/liter)	Mean log10 reduction ± SD (CFU/wound) by drug (regimen)a:			CFU/wound (mean log10 ± SD) in controls
		Retapamulin (1% ointment b.i.d.)	Mupirocin (2% ointment t.i.d.)	Fusidic acid (2% cream t.i.d.)
F306b,c,d	0.25	3.1 ± 1.3**	3.5 ± 0.6**	1.1 ± 0.1**	6.2 ± 0.5
1080c	4	2.2 ± 1.5**	1.2 ± 0.5**	1.0 ± 0.8*	6.4 ± 0.6
X32717b,c,d	8	2.3 ± 1.6**	1.6 ± 0.7**	3.0 ± 1.6**	6.7 ± 0.2
T63256b,c,d	>16	1.8 ± 1.3*	Ineffective	Ineffective	5.7 ± 0.8
S5112c,d	>16	1.6 ± 0.9**	Ineffective	Ineffective	6.1 ± 0.3

^aStatistical significance compared with untreated controls by Student's t test. *, P ≤ 0.05; **, P ≤0.01.

^bMethicillin resistant.

^cAzithromycin resistant.

^dLevofloxacin resistant.