TABLE 1.
Mean pharmacokinetic parameters of levofloxacin in male rhesus monkeys treated with 15 or 25 mg/kg once dailya
| Dose (mg/kg) | Day of dosing | Mean (SD)
|
||||
|---|---|---|---|---|---|---|
| Cmax (μg/ml) | Tmax (h) | AUCb (μg · h/ml) | t1/2 (h) | CL/F (liters/h/kg) | ||
| 15 QD | 1 | 5.36 (0.55) | 0.83 (0.29) | 22.12 (3.05) | 2.10 (0.12) | 0.69 (0.10) |
| 15 QD | 4 | 5.81 (0.68) | 0.83 (0.29) | 24.97 (2.40) | 2.21 (0.03) | 0.62 (0.06) |
| 25 QD | 1 | 8.50 (1.08) | 1.17 (0.76) | 31.79 (2.89) | 1.86 (0.28) | 0.79 (0.07) |
| 25 QD | 4 | 8.24 (1.74) | 0.83 (0.29) | 29.61 (11.78) | 1.99 (0.17) | 0.68 (0.27) |
a
The value for each pharmacokinetic parameter is the mean of three individual values, with the standard deviation presented in parentheses.
b
AUC0-∞ on day 1 versus AUC from 0 to 24 h (AUC0-24) on day 4.