TABLE 2.
Mean pharmacokinetic parameters of levofloxacin in rhesus monkeys treated with a “humanized” dosing regimen (15/4 mg/kg) for 5 daysa
| Dose (mg/kg) | Sex of monkey | Day of dosing | Mean (SD)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cmax a.m. (μg/ml) | Tmax a.m. (h) | Cmax p.m. (μg/ml) | Tmax p.m. (h) | AUC0-24 (μg · h/ml) | AUC0-12 (μg · h/ml) | AUC12-24 (μg · h/ml) | t1/2 (h) | |||
| 15/4b | M | 5 | 4.92 (0.98) | 2.33 (0.58) | 1.40 (0.14) | 14.3 (0.6) | 34.0 (3.1) | 26.1 (1.2) | 7.85 (2.22) | 3.62 (0.97) |
| 15/4b | F | 5 | 5.66 (0.79) | 2.00 (0) | 1.21 (0.40) | 14.0 (0) | 32.7 (1.6) | 26.4 (0.3) | 6.28 (1.84) | 3.43 (1.05) |
a
The value for each pharmacokinetic parameter is the mean of three individual values, with the standard deviation presented in parentheses.
b
The first daily dose administration was 15 mg/kg, followed approximately 12 h later by a 4-mg/kg dose.