TABLE 2.
Reciprocal urinary bactericidal titers for ciprofloxacin and levofloxacin in 11 volunteers tested after a single oral dose of XR ciprofloxacin (1,000 mg) versus levofloxacin (500 mg)
| Drug and strainb | Median UBT (range) for the following collection period:
|
Median AUBC (range) at 24 h | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 0-4 h | 4-8 h | 8-12 h | 12-16 h | 16-24 h | 24-28 h | 28-32 h | 32-36 h | ||
| Ciprofloxacin (XR) | |||||||||
| E. coli ATCC 25922 | 16,384 (1,024-65,536) | 4,096 (512-16,384) | 4,096 (512-8,192) | 2,048 (512-4,096) | 1,024 (128-4,096) | 512 (32-2,048)b | 512 (32-2,048) | 192 (16-1,024) | 131,072 (11,264-327,680) |
| E. coli 523 (NARa) | 512 (64-4,096) | 256 (64-512) | 256 (64-1,024) | 128 (16-512) | 64 (8-512)b | 32 (4-256)b | 16 (0-128)b | 4 (0-64)b | 6,656 (896-25,600) |
| K. pneumoniae 595 | 4,096 (512-32,768) | 2,048 (256-16,384) | 1,024 (256-4,096) | 512 (256-2,048) | 256 (64-2,048) | 256 (16-1,024)b | 128 (16-1,024) | 64 (8-512) | 36,864 (6,656-197,008) |
| P. mirabilis 414 | 8,192 (2,048-32,768)b | 4,096 (512-8,192)b | 2,048 (1,024-8,192) | 2,048 (512-4,096)b | 512 (256-2,048) | 256 (64-1,024) | 256 (32-512) | 128 (32-512) | 83,968 (26,624-221,184)b |
| P. aeruginosa 568 | 128 (16-512) | 64 (16-256) | 32 (16-64) | 16 (8-64) | 8 (2-32)b | 2 (0-8)b | 2 (0-8) | 2 (0-4) | 1,408 (240-3,712) |
| S. aureus 83 | 512 (128-4,096) | 256 (64-2,048)b | 256 (32-512)b | 128 (32-512)b | 64 (16-128)b | 32 (8-64)b | 16 (4-64)b | 8 82-32)b | 5,888 (1,920-19,968)b |
| S. saprophyticus Ho94 | 512 (128-4,096) | 256 (64-512) | 128 (32-512) | 128 (16-256) | 32 (16-128)b | 16 (4-32) | 8 (2-32) | 8 (2-32) | 3,328 (1,920-20,224)b |
| E. faecalis 60 | 128 (32-512) | 32 (16-128) | 32 (8-64)b | 16 (4-64)b | 8 (4-16)b | 2 (2-8)b | 2 (0-8)b | 1 (0-4)b | 656 (480-3,008) |
| Levofloxacin | |||||||||
| E. coli ATCC 25922 | 8,192 (256-65,536) | 4,096 (256-16,384) | 2,048 (256-16,384) | 2,048 (64-4,096) | 1,024 (64-8,192) | 1,024 (64-2,048)b | 256 (32-2,048) | 192 (16-1,024) | 81,920 (3,840-475,136) |
| E. coli 523 (NAR) | 512 (32-8,192) | 256 (32-4,096) | 256 (32-4,096) | 256 (8-1,024) | 128 (16-2,048)b | 128 (8-256)b | 32 (4-512)b | 8 (4-64)b | 6,656 (544-86,016) |
| K. pneumoniae 595 | 4,096 (256-16,384) | 2,048 (128-4,096) | 1,024 (256-8,192) | 1,024 (32-2,048) | 512 (32-2,048) | 256 (32-1,024)b | 128 (8-1,024) | 128 (16-512) | 37,888 (2,816-131,072) |
| P. mirabilis 414 | 4,096 (512-8,192)b | 2,048 (512-4,096)b | 1,024 (1,024-4,096) | 1,024 (128-2,048)b | 512 (256-2,048) | 256 (128-512) | 128 (32-512) | 64 (32-256) | 34,816 (10,752-77,824)b |
| P. aeruginosa 568 | 64 (8-256) | 32 (8-128) | 32 (8-128) | 16 (4-32) | 16 (4-64)b | 4 (2-16)b | 2 (1-16) | 2 (0-8) | 896 (144-2,688) |
| S. aureus 83 | 2,048 (256-8,192) | 512 (128-4,096)b | 512 (256-4,096)b | 256 (64-512)b | 256 (128-1,024)b | 128 (32-256)b | 64 (16-256)b | 32 (16-128)b | 21,504 (3,840-51,200)b |
| S. saprophyticus Ho94 | 512 (128-4,096) | 256 (64-512) | 128 (128-512) | 128 (32-256) | 128 (32-256)b | 32 (16-128) | 32 (4-64) | 32 (4-32) | 4,608 (1,920-20,480)b |
| E. faecalis 60 | 128 (16-512) | 64 (16-128) | 64 (32-128)b | 32 (8-64)b | 32 (8-64)b | 8 (4-32)b | 8 (2-32)b | 4 (1-8)b | 1,280 (352-3,840) |
a
NAR, nalidixic acid resistant.
b
Significantly different (P < 0.05, paired t test) for ciprofloxacin versus levofloxacin.